1. Why Cooling Agent WS-5 for Toothpaste & Oral Care
Cooling Agent WS-5 is one of the most widely used synthetic cooling agents in the global flavor, fragrance and personal-care industry. Identified by the chemical name N-[(Ethoxycarbonyl)methyl]-p-menthane-3-carboxamide (CAS 68489-14-5, FEMA 4309), it is supplied as a white crystalline powder with minimum purity of >=98%. Its cooling character is described as strongest intensity, smooth rounded profile, no bitterness.
In toothpaste & oral care, formulators choose Cooling Agent WS-5 because it delivers powerful fresh breath signal during and after brushing, mucosal-safe (no irritation), high-heat stable. The recommended dosage for this application is 0.05-0.2% in paste formula, allowing the cooling sensation to harmonize with the base flavor or fragrance without overpowering it. Premium high-impact coolant, longest-lasting smooth freshness, the gold standard for premium toothpaste & gum.
2. Technical Specifications
Appearance white crystalline powder
Purity (HPLC) >=98%
Melting Point 80-82 °C
Flash Point 190 °C
Solubility Insoluble in water; soluble in alcohol & oils
Molecular Weight 269.38
Standard GB 29938-2013
Shelf Life 24 months
3. Application Scene: Toothpaste & Oral Care
Common product formats in the toothpaste & oral care category include: Adult toothpaste, kids paste, sensitive-teeth formula, whitening gel, mouthwash, breath spray. In each of these formats, Cooling Agent WS-5 can be incorporated directly into the flavor phase, the fragrance base, or the active ingredient premix. Because the molecule is strongest intensity, smooth rounded profile, no bitterness, it integrates smoothly with menthol, mint, eucalyptus, spearmint, and fruit flavors such as strawberry, watermelon and apple.
4. Formulation Guideline & Dosage
Recommended dosage: 0.05-0.2% in paste formula. For best results, dissolve the powder in ethanol, propylene glycol, or a fractionated coconut oil (MCT) before adding to the aqueous or lipid phase. In chewing gum and compressed mint matrices the coolant can also be dry-blended directly with the sugar-free base.
Synergy tips: combine Cooling Agent WS-5 with WS-3 and WS-23 to build a layered cooling profile; add 0.5-2 ppm of sucralose or acesulfame-K if a slight sweet-cue is required to balance bitterness from actives such as caffeine, zinc or herbal extracts.
5. Why Choose Shaanxi Baisifu as Your Supplier
Shaanxi Baisifu Biological Engineering Co., Ltd. (Shaanxi, Xi'an) is a GMP-aligned manufacturer and global exporter of synthetic cooling agents. We supply Cooling Agent WS-5 in 1 kg foil bags inside 25 kg fiber drums, with complete COA, TDS and MSDS documentation. Our export markets include the EU, Russia, the Middle East, Southeast Asia, Latin America and the United States.
Our laboratory is equipped with HPLC, GC-MS and ICP-MS instrumentation to guarantee purity, residual solvent limits, and heavy-metal compliance with USP, EP, FCC and Chinese GB standards. Standard lead time for 25 kg trial orders is 3-5 working days; 500 kg production orders ship within 10-15 days.
6. Frequently Asked Questions
Q: What is the recommended dosage of Cooling Agent WS-5 in toothpaste & oral care?
A: 0.05-0.2% in paste formula. Start at the low end of the range for mild products; the high end for sensory-impact formats.
Q: Is Cooling Agent WS-5 safe for daily-use consumer products?
A: Yes. It is FEMA GRAS-approved and complies with Chinese GB standards. Toxicological studies show no irritation at the recommended dosage.
Q: Can Cooling Agent WS-5 replace menthol in a formulation?
A: Yes - it provides a clean, odorless, low-volatility cooling effect. Most formulators use it as a 30-50% menthol substitute to reduce harshness and bitterness.
Q: Does Cooling Agent WS-5 dissolve in water?
A: No. It must be pre-dissolved in ethanol, PG or a fractionated oil. Contact us for our water-dispersible pre-blend.
Q: What packaging and MOQ do you offer?
A: Standard: 1 kg aluminum foil bag inside 25 kg fiber drum. MOQ: 1 kg for samples, 25 kg for trial orders.